HBV reactivation has been reported during or after completion of HCV direct-acting antiviral therapy in HCV/HBV-coinfected patients who were not receiving HBV antiviral therapy; some cases resulted in fulminant hepatitis, hepatic failure, and death. Ideally, you should try to upgrade your browser to the latest version in order to use our full featured interaction checker. No dosage recommendation can be given for patients with severe renal impairment or ESRD. dose of one or both drugs: combo may incr. There are 111 drug interactions with Epclusa (sofosbuvir / velpatasvir). Drug Interaction Checker. Notes for Consumers: Although an interaction is possible, these drugs can be used together with caution. Both of these medications belong to the class of medications called antivirals. Highly clinically significant. Please check with a physician if you have health questions or concerns. It is possible that side effects, such as a reduced number of red blood cells, may develop if these drugs … sofosbuvir, Vosevi, Sovaldi, Mavyret, Harvoni, ribavirin. Access our free, comprehensive and user-friendly drug interaction charts Educational Videos. Carbamazepine (Induction of P-gp and CYPs) Interaction not studied. The following chart provides information regarding potentially significant drug interactions with Epclusa (the table is not all-inclusive). ASTRAL-1: Double-blind, placebo-controlled trial in GT 1, 2, 4, 5, or 6 patients (N=740). Applies to: Liver Disease, Cirrhosis. Consumer; Professional; FAQ; Note: This document contains side effect information about sofosbuvir / velpatasvir. sofosbuvir, Vosevi, Sovaldi, Mavyret, Harvoni, ribavirin. Usually avoid combinations; use it only under special circumstances. Expected: ↓ Velpatasvir. Usually avoid combinations; use it only under special circumstances. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Patients who were active injection drug users (use within 12 months), or those with a positive urine drug test at screening, were excluded from the ASTRAL pivotal trials. Minimally clinically significant. View interaction reports for Epclusa (sofosbuvir / velpatasvir) and the medicines listed below. Available for Android and iOS devices. Epclusa is contraindicated with … Select one or more newsletters to continue. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Moderate Potential Hazard, Moderate plausibility. Patients who were active injection drug users (use within 12 months), or those with a positive urine drug test at screening, were excluded from the ASTRAL pivotal trials. Potential for Other Drugs to Affect EPCLUSA 7.2 Potential for EPCLUSA to Affect Other Drugs : 7.3 Established and Potentiall y Significant Drug Interactions : 7.4 Drugs without Clinically Significant Interactions … Select one or more newsletters to continue. EPCLUSA can cause serious side effects, including: • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. However, if that is not possible or if local settings are preventing the checker … Drug Interactions Checker; A study for a 63 year old woman who takes Claritin, Epclusa, Ambien, Anoro Ellipta, Humalog Mix 75/25, Neurontin, Bentyl, Dexilant, Metformin, Ibu, Lisinopril - from FDA reports. Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. ASTRAL-1: Double-blind, placebo-controlled trial in GT 1, 2, 4, 5, or 6 patients (N=740). Whenever two or more drugs are being taken, there is a chance that there will be an interaction among the drugs. Prior to the completion of this project, many of the interactions with the HBV drugs … Moderately clinically significant. HBV reactivation has also been reported in patients using certain immunosuppressant or chemotherapeutic agents; risk of HBV reactivation associated with HCV direct-acting antiviral therapy may be increased in these patients. Interaction … Applies to: Renal Dysfunction. All patients should be tested for evidence of current or prior HBV infection by measuring HBsAg and anti-HBc before starting HCV direct-acting antiviral therapy. Drugs affecting sofosbuvir/velpatasvir. Interactions with Harvoni ® and Epclusa ® November 2016 | www.hepatitis.va.gov. Epclusa sofosbuvir 400 mg / velpatasvir 100 mg (GSI 7916). Generic Name: sofosbuvir / velpatasvir Medically reviewed by Drugs.com. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Epclusa Side Effects. Drug interactions of Epclusa include acid reducing agents that are commonly used to treat heartburn, indigestion, and GERD, such as antacids, histamine 2 receptor antagonists. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Applies to: Immunodeficiency, Infectious Hepatitis. Etoricoxib Interaction with 583 drugs. Of P-gp and CYPs ) interaction not studied greatest risk for interactions with Epclusa ( sofosbuvir / velpatasvir 100 (... Are required to treat probl… interaction Checker in the database that may with! 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