<> Une revue de littérature réalisée par Bolognesi et al. Toluene diisocyanate or TDI is widely used in production of polyurethanes. 2. 100 mg. Price (USD) Price. $25.00. Add to Cart Add. Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Methylene Bisphenyl Isocyanate. Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. 4 0 obj eye contact: may cause eye irritation. Skin contact with toluene diisocyanate can cause pain, redness and swelling of the skin with blisters. NZ Med J 63:642-647. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. 0000004058 00000 n Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. 1 0 obj 0000062501 00000 n endobj %PDF-1.5 * Many scientists believe there is no safe level of exposure to a carcinogen. %%EOF Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, … 1 15 U.S.C §2601 et seq. State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) 0000008879 00000 n stream Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Greene EJ, Friedman MA [1980]. Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. EC Number 209-544-5. );ʯ���A�B�I &����������6�b�a�_��m6�쮼f�O�����\=?�'�����̗����� >zW������9��7W�G'�� ɮn����`�۔�I��м�:v�>>���������K~gW��.�۟�G�>>b?O�I@�7��f���r���H(�)מ�B�4�,ǫ&)y�Y�g��ֿ�������S�sƅ�8U��+΅�>���9��.O-��S!�~�N��i��+��~nMT��zT�*K���y�c5b�Č�O���%. IBC carriage requirements. Certified Reference Material. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Toluene-2,6-Diisocyanate. # D-5836-02N. 0000003775 00000 n 0000001270 00000 n Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Compare. Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. 0000010616 00000 n 0000065170 00000 n 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. MDL number MFCD00002011. xref Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. 1989]. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … (February 1996). You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. Hazards Identification GHS-US classification Acute toxicity (inhal. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. [Handling Chemcials Safely 1980. p. 907]. In vitro cell transformation screening of 4 toluene diamine isomers. Main properties/hazards . Main chemical and physical properties. Linear Formula CH 3 C 6 H 3 (NCO) 2. (January 1986). 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. Email. 0000035819 00000 n SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. 8. Catalog Number Cat. 0000004899 00000 n chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. contact with product at elevated temperature s (>150c) can result in thermal burns. Isophorone Diisocyanate. CAS# 91-08-7. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … 0000001666 00000 n The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! 1989]. Potential explosion if stored in polyethylene containers due to … Hazardou s in case of skin contact (permeator). Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . This is based on test results presently Unit. Density. 0000007141 00000 n 0000011484 00000 n Ship Type. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. IBC chapter. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. : 584-84-9 Toluene-2,4 / 2,6-diisocyanate mixture CAS No. 0000003317 00000 n Product form : Substance Substance name : Toluene CAS-No. Risk of fire and explosion as a result of … Toluene-2,4-Diisocyanate. products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). 0000001487 00000 n Molecular Weight 174.16 . 0000002356 00000 n (June 1998). International Chemical Safety Cards (ICSC). 0000000016 00000 n (February 1996). 4th edition. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). Reaction with water to form Carbon Dioxide [Merck 11th ed. R. Schwalm, in Encyclopedia of Materials: Science and Technology, 2001 Ambient (>5 °C) Safety Data Sheet SDS. Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. Methylene Bisphenyl Isocyanate. Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. Le National Toxicology Program (NTP, 2005) classifie le diisocyanate de toluène (mélange d'isomères) comme une substance raisonnablement anticipée cancérogène (R). 0000052031 00000 n Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. startxref 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. (January 1986). Each notification may be associated with multiple companies. National Institute for Occupational Safety and Health (NIOSH). Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Reproductive Hazard health hazards acute and chronic: target organs: eyes, skin, respiratory tract. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 2 0 obj Caution is advised. For more detailed information, please visit ECHA C&L website … The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Tank Type. Similarly, spray mists can impose a significant health hazard. Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. skin contact: prolonged or repeated skin contact may cause irritation. CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Mutat Res 79:363-375. Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. (February 1996). trailer %���� National Institute for Occupational Safety and Health (NIOSH). Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. [Handling Chemcials Safely 1980. p. 907]. (April 1996). Toluene-2,4-Diisocyanate. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Gunter BJ [1975]. 7.6 1,2,4-Trichlorobenzene (TCB). For more detailed information, please visit ECHA C&L website … 0000006492 00000 n Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). (April 1996). Methyl Isocyanate. Identification . ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation 0000003819 00000 n TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). Slightly hazardous in case of skin contact (corrosive). Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). 26 0 obj<> endobj Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. Reaction with water liberates carbon dioxide. Boiling points. Each notification may be associated with multiple companies. 2,6-Toluene diisocyanate. Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. 77, No. inhalation: harmful if inhaled, may cause allergic respiratory reaction such as asthma. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . H319 Causes serious eye irritation. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. ���i�����LAװ�BjL���6� 90-117. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Reaction with water to form Carbon Dioxide [Merck 11th ed. Key health and ecological effects (hazard) Risk assessment outcomes. According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … 17034 Classification. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. The polyurethanes have found wide applications as solid elastomers, flexible foaming materials etc. When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. <>>> 0000000974 00000 n Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity: 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity. View other preventive measures for 2,4-toluene diisocyanate in WISER. * Many scientists believe there is no safe level of exposure to a carcinogen. Flash point. 1. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. 0000005710 00000 n Viscosity @ 20°C Vapour pressure @ 20°C. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. ���Y? 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